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. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

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© 2023 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Effects of intrarenal artery infusions of inosine and guanosine on renal excretory function. Inosine (A, C, E) or guanosine (B, D, F) was infused directly into the renal artery of anesthetized rats at increasing doses (0 [vehicle only; basal], 0.01, 0.1 and 1 µmol/kg per minute [min]). Each dose of inosine or guanosine was administered for 30 minutes, timed collections of urine were obtained from the ureter between 10 and 30 minutes after initiating a given dose of inosine or guanosine, and urine volumes (A and B) and excretion rates of sodium (C and D) and glucose (E and F) were determined. Values are means and SEMs for the indicated sample size (n). *P<0.05 vs 0 (vehicle; basal).