Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Figure 3. — Effects of 8-aminoguanine in wild-type (WT) Dahl salt-sensitive rats (Dahl SS rats) versus Dahl salt-sensitive rats with knockout of A_2B receptors (A_2B-KO Dahl SS rats). WT Dahl SS rats (A, C, E) and A_2B-KO Dahl SS rats (B, D, F) were placed on a high salt diet (4% NaCl) for 1 week. Next, rats were anesthetized, and timed urine collections were obtained from the ureter from 0 to 30 minutes (min; Period 1), 40 to 70 minutes (Period 2), and 85 to 115 minutes (Period 3) into the protocol. Rats received an IV injection of 8-aminoguanine (33.5 µmol/kg) immediately after Period 1. Urine volumes (A and B) and sodium (C and D) and glucose (E and F) excretion rates were determined. Values are means and SEMs for the indicated sample size (n). *P<0.05 vs Period 1.