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. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

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© 2023 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — Effects of 8-aminoguanine on medullary blood flow (MBF) in rats pretreated with an A_2A receptor antagonist, an A_2B receptor antagonist or both an A_2A and A_2B receptor antagonist. Anesthetized rats were pretreated intravenously with either vehicle (A; Control Group), 10 mg/kg of ZM 241385 (B; A_2A Antagonist Group), 30 mg/kg of PSB 1115 (C; A_2B Antagonist Group) or ZM 241385 plus PSB 1115 (D; A_2A + A_2B Antagonist Group), and 15 minutes later MBF was averaged over 30 minutes (Basal). Next, rats received an IV injection of 8-aminoguanine (33.5 µmol/kg), and after ≈1 hour MBF was averaged over 30 minutes (8-Aminoguanine). P values are from paired t-tests. Values are means and SEMs for the indicated sample size (n).