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. 2023 Feb 17;11(6):252. doi: 10.21037/atm-22-6346

Figure 1.

Figure 1

CircRBM33 is highly expressed in H1975-OR cells than H1975 cells. (A) Volcano plot showing all differential circRNAs sequenced in the transcriptome, where blue indicates down-regulated circRNAs and red indicates up-regulated circRNAs. (B) Heatmap showing the expression of all differential circRNAs in each sequenced sample. (C) qRT-PCR result found that circRBM33 was significantly higher in H1975-OR cells than in H1975 cells. (D) Gel electrophoresis result showed the band of circRBM33, indicating that circRBM33 can be expressed in a loop. ****, P<0.0001; NS, no significant; H1975-OR, H1975 osimertinib-resistant; circRNA, circular RNA; qRT-PCR, quantitative reverse transcriptase-polymerase chain reaction.