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. 2022 Aug 5;30(3-4):309–322. doi: 10.1038/s41434-022-00358-x

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© The Author(s) 2022

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Fig. 6 — Male and female 8- to 11-week old NSG HLA-A*02 mice were injected intravenously with different batches of TX200 Tregs that were isolated with 2 different gating strategies (TR101 and TR100) and characterized by different levels of FOXP3 hypomethylation. Mice were observed for up to 27 days or until ethical endpoints were reached (represented by a cross). Evolution of GvHD scores is shown based on scoring in 5 categories (0: no findings, 1: mild, 2: moderate, 3: severe) combined into a total score. Data are presented as mean ± SEM with n = 5 for 80.8% hypomethylation, n = 3 for 92% and 89.1%, n = 20 for 69%, n = 2 for 98%, and n = 5 for 100%. Average percentage of transduction was 59.5 ± 2.7% (mean ± SEM) and cells were on average 95.3 ± 2.8% CD4⁺/CD45RA⁺/CD25⁺/FoxP3⁺ (mean ± SEM).