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. 2023 Apr 3;30(4):527–538. doi: 10.1038/s41594-023-00960-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — A, RT–qPCR data for HTRA4 and TM2D2 in hTSC populations treated with lentiviral CRISPR constructs carrying either no sgRNAs or sgRNAs that excise the MER41B element highlighted in Fig. 5a (n = 6). B, TWIST1 expression in EVT and SynT derived from hTSC populations with no sgRNAs or sgRNAs that excise the MER41B element highlighted in Fig. 5c. C, Expression of stem cell (TEAD4), SynT (SDC1, CGB3) and EVT (MMP2, HLAG) markers in cell populations with no sgRNAs or sgRNAs that excise the LTR10A element highlighted in Fig. 5b. D, As in C, but for the LTR8B element in Fig. 5d. No significant differences were detected in any of the data after two-sided Wilcoxon tests with multiple comparisons correction. Please see the data availability statement for details on source data.