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. 2023 Apr 3;30(4):527–538. doi: 10.1038/s41594-023-00960-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Proportion of H3K27ac-marked elements from selected ERV families bearing motifs for the transcription factors on the y axis. b, Genome browser snapshots of transcription-factor CUT&Tag/RUN data, showing examples of enrichment over ERVs. c, Repeat family-wide enrichment for peaks from transcription-factor CUT&Tag/RUN data on hTSCs. H3K27ac-enriched families in hTSCs or hESCs are highlighted. d, Schematic and alignment of LTR10 and LTR8 subfamilies showing the presence of FOSB::JUNB (that is, AP-1) motifs in the genome-wide consensus sequence and/or in a consensus of the H3K27ac-marked elements. e, Mean CUT&Tag profiles for JUN and JUND over LTR10 and LTR8 subfamilies. See the data availability statement for details on source data for a, c and e.