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. 2023 Apr 18;13:6277. doi: 10.1038/s41598-023-33508-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of tumors in KPC-LSIY mice. (A) In vivo luciferase expression in Pdx1-cre + /LSIY + by MuriGlo-assisted CT scan. (B) Survival curves of KPC mice compared to KPC-LSIY mice. (C) Representative histology of premalignant progression in KPC-LSIY mice. (D) Representative histology of moderately differentiated and sarcomatoid PDAC phenotypes, liver metastasis, lung metastasis, as well as thymic lymphoma and in KPC-LSIY mice. (E) Representative histology of orthotopic and subcutaneous tumors using KPC (PK5) and KPC-LSIY (PK5L)-derived tumor cell lines.