Figure 3.

Role of direct presentation in Trm formation. (a) Rag^−/− mice were reconstituted with a 1:1 mix of splenocytes from wt and Kaede mice, or a 50:50 mice of splenocytes from wt and Kaede CCR7^−/− mice. Following reconstitution, mice were implanted sc. with tumors and tumor-infiltrating CD8⁺CD103⁺ T cells were analyzed for Kaede expression after 14 days. (b) Representative gating on CD103⁺ T cells, and Kaede expression by these cells. (c) Summary of percent of CD103⁺ cells that are Kaede⁺ in mice given Kaede or Kaede CCR7^−/− cells. Key: ** = p < 0.01. Results are representative of two or more experiments.