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. 2023 Apr 18;13:6277. doi: 10.1038/s41598-023-33508-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CD4 depletion minimally impacts CD8 T cell responses to tumor implantation. (a) PK5L1940 pancreatic adenocarcinoma cells were injected sc. into C57BL/6 mice, C57BL/6 mice treated with anti-CD40L on d0, 1, and 2, or C57BL/6 mice treated with anti-CD4 on d-1. ii) Representative flow cytometry of tumor infiltrating T cells 14d following implantation. Plots show gated CD90.2⁺ T cells, and subgates for CD8⁺ T cells, and SIY-pentamer⁺ CD8 T cells. (b) Summary of T cell infiltration of PK5L1948, PK5L1941, PK5L1932, and PK5L1940 tumors derived from Pdx-Cre+/− Kras(G12D)+/− Trp53(R172H)+/− Luciferase-SIY + mice implanted sc. into C57BL/6 mice or C57BL/6 mice treated with anti-CD4 on d-1. Graphs show tumor the proportion of CD4, CD8, CD8 SIY-specific T cells, and CD103 expression on CD8 SIY-specific T cells. Key: NS = not significant; * = p < 0.05; ** = p < 0.01; *** = p < 0.001; **** = p < 0.0001. Results are representative of two or more experiments.