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. 2023 Apr 18;13:6277. doi: 10.1038/s41598-023-33508-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CD8 T cell can provide CD40L for Trm formation. (a) Rag^−/− mice were adoptively transferred with splenocytes from wt or CD40L^−/− mice, then following reconstitution, implanted sc. with PK51940 tumors. d14 tumors were harvested and analyzed for tumor infiltrating CD8 T cell phenotypes. Flow plots show representative CD103 expression in tumor CD8 T cells from mice reconstituted with (i) wt or (ii) CD40L^−/− splenocytes. (iii) Summary of CD103 expression in tumor T cells. (b) Rag^−/− mice were reconstituted with CD8-depleted CD40L^−/− splenocytes, along with purified CD40L^−/− CD8⁺ splenocytes, or purified wt CD8⁺ splenocytes. Following reconstitution, mice were implanted sc. with PK51940 tumors. d14 tumors were harvested and analyzed for tumor infiltrating CD8 T cell phenotypes. Flow plots show representative CD103 expression in tumor CD8 T cells from mice reconstituted with (i) CD40L^−/− CD8 T cells, or (ii) wt CD8 T cells. (iii) Summary of CD103 expression in tumor T cells. . Key: ** = p < 0.01. Results are the combination of two experiments.