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. 2023 Apr 18;6:403. doi: 10.1038/s42003-023-04640-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative dorsal views of whole larvae at 8–9 dpf for wild-type (WT), Znt5^+/-;Znt7^-/-, and Znt5^-/-;Znt7^-/- medaka. The Znt5^-/-;Znt7^-/- medaka did not hatch, and thus is shown after manual removal of the chorion. b Representative lateral views of embryos at 8–9 dpf for Znt5^-/-;Znt7^-/- (left) and Znt5^+/-;Znt7^-/- (right) medaka before hatching. c Transmission electron microscopy (TEM) shows irregular melanosomes with less electron dense pigment in Znt5^-/-;Znt7^-/- medaka compared with those in WT and Znt5^+/-;Znt7^-/- medaka. d Melanin content was decreased in Znt5^-/-;Znt7^-/- mutant medaka compared with that in Znt5^+/-;Znt7^-/- littermate (n = 3). Statistical significance was analyzed by Student’s t-test. **p < 0.01. In a–c, each analysis was performed on more than three individual medaka, and in d, the experiments were performed at least three times, and representative results are shown.