Table 1.
Overview on the diagnostic accuracy of the CSF RT-QuIC in different studies
| Species | Amino acid res | Accuracy for sCJD CSF diagnostics Sensitivity / Specificity |
References | |
|---|---|---|---|---|
| Human | 23–231 | > 80% (27/34) | 100% (0/49) | Atarashi et al. 2011 |
| Hamster | 23–231 |
89% (109/123) 88.2% (148/179) |
99% (1/103) 99.4% (1/163) |
McGuire et al. 2012 Lattanzio et al. 2017 |
| 90–231 |
94% (106/113) 92% (102/111) 95% (60/63) |
100% (0/64) 98.5% (1/67) 100% (14/14) |
Orrú et al. 2015a; Groveman et al. 2016 Foutz et al. 2017 Foutz et al. 2017 |
|
| 90-231 | 96% (58/61) | 100% (0/80) | Fiorini et al. 2020 | |
| Bank vole | 23-230 | 88.6% (70/79) | 91.2% (5/57) | Orrú et al. 2015b; Mok et al. 2021 |
| Hamster-sheep chimera |
Hamster 23–137 Sheep 141–234 |
80% (51/64) 89% (163/183) |
99% (2/400) 100% (0/118) |
Hermann et al. 2018 |