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. 2023 Apr 18;14:2206. doi: 10.1038/s41467-023-37948-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Representative immunofluorescence images of the sciatic nerve 14 days after implantation with T-ECH, sham group, and stainless steel (S-100 in red; NFM in yellow; Iba1 in green; DAPI in blue). Scale bar = 100 μm. c–e Normalized fluorescence intensity of T-ECH, stainless steel, and sham group respectively for (c) S-100, (d) NFM, and (e) Iba1. Data are plotted as mean values and the error bar represents the standard deviation. One-way ANOVA and Tukey’s multiple comparison tests were employed for statistical analysis; *P < 0.05 ***P < 0.001 with a confidence level of 95%. (n = 5 devices examined with individual mice for S100 and NFM of sham. n = 7 for S100 and NFM of T-ECH and stainless steel, n = 7 for Iba1 of all groups. For comparison of S-100 intensity, P = 0.03 for both between T-ECH and stainless steel and between Sham and stainless steel. For comparison of Iba1 intensity, P = 0.0004 for both between T-ECH and stainless steel and between Sham and stainless steel).