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α-Glucosidase inhibition of 4-hydroxyquinolinone hydrazone hybridsa.
 | ||
|---|---|---|
| Compounds | R | IC50 (µM) |
| 6a | H | 382.6 ± 0.9 |
| 6b | 2-F | 247.0 ± 1.1 |
| 6c | 4-F | 195.3 ± 1.2 |
| 6d | 4-Cl | 131.6 ± 0.3 |
| 6e | 3-Br | 436.7 ± 1.0 |
| 6f | 4-Br | 520.2 ± 1.5 |
| 6g | 4-NO2 | 120.5 ± 0.8 |
| 6h | 4-CH3 | 136.7 ± 0.5 |
| 6i | 4-OCH3 | 259.0 ± 1.0 |
| 6j | 2-OH | 154.8 ± 0.1 |
| 6k | 3-OH | 196.3 ± 0.7 |
| 6l | 2-OH-5-Br | 94.2 ± 1.0 |
| 6m | 2-OH-5-NO2 | 93.5 ± 0.6 |
| 6n | 2,4-OH | 187.8 ± 0.3 |
| 6o | 3-OCH3-4-OH | 575.6 ± 0.4 |
| Acarbose | 752.0 ± 2.0 | |
aData represented in terms of mean ± SD.
