Table 2.

The predicted binding energy of 6l and 6m derivatives with the desired enzyme.

Compound	Moiety	Residue	Type of interaction	Distance (Å)
6l	Quinolinone	Phe310	Aliphatic interaction	3.45
	Quinolinone	Tyr313	Aliphatic interaction	3.32
	Quinolinone	Arg312	Salt bridge	4.33
	Quinolinone	Ash408	H-bound	2.53
	C=O	Ash408	H-bound	1.83
	OH	Asp349	H-bound	1.83
	OH	Ash439	H-bound	2.07
6m	Quinolinone	Hie239	Pi-cation	3.37
	Quinolinone	Lys155	H-bound	1.92
	OH	Ash408	H-bound	2.56
	Benzylidene	Ash408	Aliphatic interaction	3.15
	NO2	Asp349	Salt bridge	3.83
	NO2	Arg439	Salt bridge	2.43