Table 2.
Characteristics of ICU stay according to proposed IrAE causality at ICU discharge (n = 110 patients)
| All n = 110 |
Unlikely causality n = 66 (60) |
Likely causality n = 44 (38) |
P-value | |
|---|---|---|---|---|
| At ICU admission | ||||
| SAPS II |
40 [34–50] Miss. = 10 |
42 [34–49] Miss. = 5 |
39 [34–52] Miss. = 5 |
0.84 |
| Reason for ICU admission | 0.09 | |||
| Respiratory | 66 (60) | 38 (58) | 28 (64) | |
| Colitis | 14 (13) | 8 (12) | 6 (14) | |
| Cardiovascular | 13 (12) | 12 (18) | 1 (2) | |
| Metabolic | 11 (10) | 5 (8) | 6 (14) | |
| Neurologic | 6 (5) | 3 (5) | 3 (7) | |
| During ICU stay | ||||
| Corticosteroids | 54 (49) | 17 (26) | 37 (84) | < 10–4 |
| Vasopressor | 26 (24) | 14 (21) | 12 (27) | 0.46 |
| High flow oxygen | 41 (37) | 20 (30) | 21 (48) | 0.06 |
| NIV | 22 (24) | 14 (21) | 8 (18) | 0.70 |
| IV | 25 (23) | 13 (20) | 12 (27) | 0.35 |
| ECMO | 1 (1) | 1 (2) | 0 | … |
| Dialysis | 6 (5) | 3 (5) | 3 (7) | … |
| Treatment-limitation decisions | 54 (49) | 35 (53) | 19 (43) | 0.31 |
Qualitative variables are expressed as n (%) and quantitative variables as median [interquartile range 25–75%]
ECMO, extracorporal membrane oxygenation; ICU intensive care unit; irAE immune-related adverse event; IV invasive ventilation; NIV non-invasive mechanical ventilation; Miss., missing data; SAPS, simplified acute physiology score