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Regulation of RIPK1 and downstream effect. After stimulated by TNF-α, TRADD, TRAF2, RIPK1 and cIAPs would recruit to the intracellular terminus of TNFR1, then RIPK1 is ubiquitinated to form complex I, activating NF-κB and MAPK pathway. When RIPK1 has been deubiquitinated, the cell death pathway would be activated, triggering necroptosis, apoptosis and pyroptosis.
