Table 3.

Study on RIPK1 and downstream sites in sepsis model.

Studies	Inducer	Species	Target Organs	Conclusion	Ref.
1	LPS	Mouse	Lung	Inhibition of necroptosis attenuates injury in subjects with ARDS	(74)
2	LPS	Mouse	Lung	RIPK3 knockdown attenuates ARDS-induced injury	(75)
3	LPS	Mouse	Lung	Necrotic apoptosis predominates upon stimulation with higher LPS doses rather than with lower doses	(75)
4	LPS	piglet	Intestine	The intestinal epithelial injury was attenuated by RIPK1 inhibition, and an increased level of MLKL phosphorylation was observed	(13)
5	LPS	piglet	Liver	Inhibition of RIPK1 with Nec-1 attenuates LPS-induced liver injury	(78)