Table 5.

RIPK1 inhibitors and their effect.

Studies	Drug	Species	Model	Conclusion	Ref.
1	Nec-1	Mice	TNF induced SIRS	Nec-1 Administration Prevents Mortality, Cell Death, and Sustained Inflammation Associated with TNF-Induced SIRS	(23)
2	Nec-1	Rat	oleic acid-induced acute respiratory distress syndrome	Nec-1 pretreatment reduced necroptosis by inhibiting RIPK1- RIPK3-MLKL pathway in OA-induced ARDS and decreased aggregation of inflammatory cells and TNF-a level in BALF	(89)
3	Nec-1; RIPA56	Rat	LPS/GalN induced acute on chronic liver failure	NEC-1 treatment prevents the occurrence of ACLF, and RIPA56 prevents RIPK1/RIPK3 mediated necroptosis	(90)
4	primidone	C57BL/6JRj; MEF; Cell lines	TNF induced SIRS	Primidone can block the activity of RIPK1 in various cell types, preventing cell death and reducing the release of pro-inflammatory cytokines. Improves TNFα-treated mice hypothermia, lung injury and mortality	(91)
5	ZB-R-55	Mouse	LPS/TNF-induced sepsis	ZB-R-55, administered orally at 10 mg/kg, showed protection from hypothermia, cytokine storm and survival rate.	(92)
6	SAR443122	Homo Spain	COVID-19 infection	No result publication	(93)
7	DNL104	Homo Spain	TNF -treated PBMC from healthy donors	DNL104 can reduce phosphorylation of RIPK1 in TNF+zVAD treated PBMC.	(94)