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. 2023 Apr 5;10:1099880. doi: 10.3389/fnut.2023.1099880

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Copyright © 2023 Mokgalaboni and Phoswa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Corchorus olitorius in a rodent model of diabetes induced by HFD and intraperitoneal injection of streptozotocin (STZ) or monohydrate alloxan in rodents. This is followed by a moderate decrease in the size of adipose tissue and a subsequent decrease in leptin concomitant to increased adiponectin levels. C. olitorius reduce inflammation through the reduction of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1-beta (IL-1β). The anti-hyperglycemic potential of C. olitorius is demonstrated by a decrease in total cholesterol levels, triglyceride, low-density lipoprotein-cholesterol (LDL-c), and increased high-density lipoprotein (HDL-c). Also, reduced blood glucose and glycated hemoglobin demonstrate its effect on basic glycemic parameters.