Table 3.

Cox model after adjusting for confounding factors on PFS for first-line therapy (N=922).

Characteristic	HR (95% CI)	p-value
Start of first-line therapy		0.7059
2000-2009	1
2010-2013	0.92 (0.78: 1.09)
2014-2017	1.03 (0.86: 1.23)
Age at first-line therapy	1 (0.99: 1.01)	0.7059
Primary tumor site		0.0092
Intrahepatic	1
Extrahepatic	0.88 (0.74: 1.05)
Gallbladder	1.18 (0.99: 1.41)
Ampullary tumor	0.69 (0.51: 0.94)
Disease status		0.0835
Locally-advanced	1
Metastatic	1.2 (1.02: 1.42)