TABLE 3.
The changes of liver metabolism profile as for bile secretion pathways.
| Liver metabolite | HFD vs. ND | VC vs. HFD | VD vs. HFD | VC + VD vs. HFD | Polarity mode |
|---|---|---|---|---|---|
| Choline | ↓ | ↑ | positive | ||
| Taurocholic acid | ↓ | ↑ | positive | ||
| Lithocholic acid | ↓ | positive | |||
| Hydrocortisone | ↑ | positive | |||
| Bilirubin | ↑ | ↓ | positive | ||
| Glutathione | ↑ | positive | |||
| Uric acid | ↓ | ↓ | negative | ||
| Chenodeoxycholic Acid | ↑ | ↑ | negative | ||
| Prostaglandin E2 | ↑ | ↑ | negative | ||
| Serotonin | ↑ | ↑ | negative | ||
| Deoxycholic acid | ↑ | ↑ | negative | ||
| Cholic acid | ↑ | ↑ | negative | ||
| Folic acid | ↑ | ↑ | negative | ||
| Thromboxane B2 | ↑ | ↑ | negative |
ND, normal diet group; HFD, high-fat diet group; VC, Vitamin C group; VD, Vitamin D3 group; VC + VD, Vitamin C + Vitamin D3 group.