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. 2023 Apr 5;17:1096720. doi: 10.3389/fnbeh.2023.1096720

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Copyright © 2023 Isotalus, Carr, Blackman, Averill, Radtke, Selwood, Williams, Ford, McCullagh, McErlane, O’Donnell, Durant, Bartsch, Jones, Muñoz-Neira, Wearn, Grogan and Coulthard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L-DOPA and slow-wave sleep duration. Longer slow-wave sleep duration was correlated with better memory for strongly encoded information on placebo (Spearman’s ρ = 0.447, p = 0.009, p_corrected = 0.012, orange), but after L-DOPA this relationship disappeared (ρ = 0.043, p = 0.810, green). The two correlations were different (r-to-z = 2.221, p = 0.026) (Lee and Preacher, 2013). A robustness check analysis where outlier data was excluded yielded similar results. Therefore, L-DOPA does not increase the relative effect of re-exposure by merely increasing slow-wave sleep. Lines of best fit are for illustration.