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. 2023 Apr 12;19:434–439. doi: 10.3762/bjoc.19.33

Table 2.

Inhibitory constants of the studied of α- and β-fluorinated aminophosphonic acid sodium salts towards bovine cathepsin C.

Dipeptide Inline graphic
9
KI ± SD [mM]		 Inline graphic
11
KI ± SD [mM]
Phe-Ala
(a) -CH3 		0.603 ± 0.1 0.733 ± 0.087
Phe-Val
(b) -CH(CH3)2 		0.0951 ± 0.05 1.869 ± 0.171
Phe-Leu
(c) -CH2CH(CH3)2 		0.309 ± 0.066 0.847 ± 0.38
Phe-Ile
(d) -CH(CH3)CH2CH3 		0.273 ± 0.15 up to a concentration of 0.37 mM, it does not inhibit activity;
at a higher concentration, it precipitates
Phe-Phe
(e) -CH2Ph		 precipitates in a buffer precipitates in buffer