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. 2023 Apr 5;14:1074837. doi: 10.3389/fphar.2023.1074837

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Copyright © 2023 Yu, Qian, Tian, Yang, Li, Xu, Chen, Yang, Hao, Liu, Zhong, Yang, Chen, Min and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linggui Zhugan Decoction antagonizes the oxidative stress in rats with heart failure and reduces the mitochondrial damage in myocardial cells. (A, B) JC-1 staining was used to observe the effect of Linggui Zhugan Decoction on mitochondrial membrane potential levels (n = 5). (C, D) ELISA was used to test the effect of Linggui Zhugan Decoction on serum oxidative stress indicators in rats with heart failure (n = 7). *p < 0.05 vs. sham group; **p < 0.01 vs. sham group; ***p < 0.001 vs. sham group; ^# p < 0.05 vs. model group; ^## p < 0.01 vs. model group; ^### p < 0.001 vs. model group.