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(A) Demonstration of how data binning results in the lost ability to detect smaller features. Bottom: Binning of Hi-C data within a 500 kb region. Contact map from Rao et al., 2014. Top: The same binning of an image depicting the Carina Nebula from the James Webb Space Telescope; Credit: NASA. (B) Histogram of the reported number of combined contact pairs for Hi-C experiments uploaded to the 4DNucleome database.
