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. 2023 Apr 19:105142. Online ahead of print. doi: 10.1016/j.micinf.2023.105142

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© 2023 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Permissiveness of HHD-DR1.ACE2^Hu1 and HHD-DR1.ACE2^Hu2 transgenic mice to SARS-CoV-2 replication. hACE2⁺ offspring from the founders #8, #9 (HHD-DR1.ACE2^Hu1) or #11 (HHD-DR1.ACE2^Hu2), resulting from a conventional DNA-based transgenesis, or B6.K18-hACE2^IP-THV positive control mice were inoculated i.n. with 0.3 × 10⁵ TCID₅₀/mouse of SARS-CoV-2 Delta variant. A. Lung and brain viral RNA contents were determined by E- (top) or sub-genomic Esg- (bottom) specific qRT-PCR at 4 dpi. Red lines indicate the qRT-PCR detection limits. B. Quantification of hACE-2 mRNA in the lung and brain of the same mice. Statistical significance was evaluated by one-way Anova (*= p < 0.05, **= p < 0.01, ***= p < 0.001).