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. 2023 Apr 19:105142. Online ahead of print. doi: 10.1016/j.micinf.2023.105142

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© 2023 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 3 — Permissiveness of HHD-DR1.ACE2^Hu1/2/3 mice to replication of SARS-CoV-2 Omicron BA.1 or BA.5 sub-variants. HHD-DR1.ACE2^Hu1/2/3 mice or B6.K18-hACE2^IP-THV positive control mice were inoculated i.n. with 0.3 × 10⁵ TCID₅₀/mouse of SARS-CoV-2 Omicron BA.1 or BA.5. A. Lung and B. brain viral RNA contents were determined by E-specific (top) or sub-genomic Esg-specific (bottom) qRT-PCR at 4 dpi with Omicron BA.1. C-D. Comparative quantification of hACE-2 mRNA in the lung and brain of individual B6.K18-hACE2^IP-THV or HHD-DR1.ACE2^Hu1/2/3 transgenic mice. E-F. Lung and brain viral RNA contents were determined by E-specific (top) or sub-genomic Esg-specific (bottom) qRT-PCR at 4 dpi with Omicron BA.5. Statistical significance was evaluated by one-way Anova (*= p < 0.05, **= p < 0.01). ND = Not determined.