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. 2023 Apr 5;17:1135227. doi: 10.3389/fncel.2023.1135227

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Copyright © 2023 Hu, Zhou, Wang, Ma, Ma, Yu, Peng, Huang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EA treatment improved the CB1R expression and mitochondrial biogenesis. (A) Photographs of reprehensive bands of CB1R, NRF1 and TFAM. (B) The exposure of PSD inhibited CB1R expression in hippocampus, which was reversed by EA treatment (n = 6, **P < 0.01). (C) Quantitative changes in NRF1 in the hippocamps after PSD or EA procedure. PSD attenuated the protein expression of NRF1, whereas EA treatment reversed this reduction (n = 6, **P < 0.01). (D) PSD operation reduced the abundance of TFAM, EA treatment reversed this decrease (n = 6, **P < 0.01).