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. 2023 Apr 5;17:1135227. doi: 10.3389/fncel.2023.1135227

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Copyright © 2023 Hu, Zhou, Wang, Ma, Ma, Yu, Peng, Huang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The improved cognitive outcome produced by EA treatment was reversed by the mutant of CB1R. (A–C) Neither PSD, EA nor CB1R knockdown affected the number of total arm entries (A). EA treatment significantly improved the exploring outcome of spatial working memory (B) and spatial cognitive ability (C) in Y-maze test, this effect was reversed by the supplementation of AM251 and CB1R-shRNA. (D) The procedure of PSD, EA, AM251 and CB1R-shRNA didn’t alter the time of mice spent exploring two identical object A or object B during the familiarization period. (E) EA treatment increased the time of mice spent exploring familiar object A or B and novel object C during the recognition period, whereas this effect was abolished by the deficiency of CB1R (n = 8, *P < 0.05 vs. familiar object A or B).