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Implications of NMDAR activation-induced nNOS-PSD-95 and nNOS-CAPON associations in neurological and neuropsychiatric disorders. ZL006 disrupts the nNOS-PSD-95 interaction and ZLc002 uncouples nNOS and CAPON and shows significant beneficial effects on stroke, PD, AD, chronic pain, MDD, generalized anxiety disorder, PTSD, and addiction. NMDAR, N-methyl-D-aspartate receptor; PD, Parkinson's disease; AD, Alzheimer's disease; PTSD, post-traumatic stress disorder.
