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. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: J Med Chem. 2022 Dec 2;65(24):16432–16450. doi: 10.1021/acs.jmedchem.2c01300

Figure 3.

Figure 3.

Figure 3.

Screening of SOS1 PROTAC candidates for SOS1 degradation in SW620 after treatment for 6 hours. (A) SW620 cells were treated with the corresponding compounds for 6 hours followed by immunoblotting. SOS1 levels were normalized to that treated by DMSO as control with 1.0 as the absence of SOS1 degradation. (B) A summary of SOS1 degradation after treatment with the corresponding compounds for 6 hours in SW620 cells. The quantities of SOS1 were summarized as mean and standard deviation.