Table 2.
Summary of explanatory variables pre- and post-intervention
| Pre- intervention (N = 248) | Post-intervention (N = 773) | P-value | |
|---|---|---|---|
| Demographics | |||
| Age (years) mean (SD) | 62 (15.97) | 62 (15.76) | 0.60 |
| Gender, male (n/%) | 136 (55%) | 419 (54%) | 0.88 |
| BMI mean (SD) | 29 (1056) | 28 (9.73%) | 0.22 |
| Criterion to determine time zero (n/%) | |||
| Bilirubin increase | 10 (4%) | 23 (3%) | 0.41 |
| Creatinine increase | 8 (3%) | 12 (2%) | 0.11 |
| INR prolonged | 13 (5%) | 36 (5%) | 0.73 |
| Lactate level | 107 (43%) | 279 (36%) | 0.05 |
| ED documentation | 9 (4%) | 23 (3.0%) | 0.67 |
| Low platelets | 3 (1%) | 15 (2%) | 0.58 |
| Systolic blood pressure | 63 (25%) | 291 (38%) | < 0.01 |
| Ventilator use | 34 (14%) | 86 (11%) | 0.30 |
| Severity of sepsis (n/%) | |||
| Sepsis | 41 (17%) | 138 (18%) | 0.70 |
| Severe sepsis | 57 (23%) | 122 (16%) | 0.01 |
| Septic shock | 150 (60%) | 513 (66%) | 0.09 |
| SEP-1 compliance and ED boarding time | |||
| Compliance with SEP-1 (n/%) | 165 (67%) | 511 (66%) | 0.94 |
| Abx time (mins) median (IQR) from time zero | 44 (17,90) | 52 (22,108) | 0.04 |
| ED LOS (hours) ED median (IQR) | 10 (6,15) | 9 (6, 15) | 0.19 |