Table 3. Risk of Overall High Refractive Error in Offspring According to the Timing and Severity of Maternal Preeclampsiaa.
| Cases, No. | Rate, per 1000 person-years | Hazard ratio (95% CI) | ||
|---|---|---|---|---|
| Crude | Adjustedb | |||
| Timing of preeclampsia | ||||
| Late onset | 321 | 0.53 | 1.15 (1.03-1.28) | 1.20 (1.07-1.34) |
| Early onset | 293 | 1.03 | 2.17 (1.93-2.44) | 1.80 (1.60-2.02) |
| Severity of preeclampsia | ||||
| Moderate | 426 | 0.59 | 1.28 (1.16-1.41) | 1.28 (1.16-1.41) |
| Severe and HELLP | 188 | 1.07 | 2.29 (1.98-2.64) | 1.93 (1.67-2.23) |
| Interaction for timing and severity of preeclampsia | ||||
| Late onset × moderate | 261 | 0.50 | 1.10 (0.98-1.25) | 1.18 (1.05-1.34) |
| Late onset × severe or HELLP | 60 | 0.65 | 1.39 (1.08-1.79) | 1.25 (0.97-1.62) |
| Early onset × moderate | 165 | 0.82 | 1.72 (1.47-2.00) | 1.46 (1.25-1.70) |
| Early onset × severe or HELLP | 128 | 1.55 | 3.27 (2.75-3.90) | 2.59 (2.17-3.08) |
Abbreviation: HELLP, hemolysis, elevated liver enzyme level, and low platelet count.
a
Includes moderate preeclampsia, severe preeclampsia, and HELLP syndrome.
b
Adjusted for calendar year, sex, singleton, parity, maternal age, maternal smoking, maternal cohabitation, maternal country of origin, maternal residence, maternal education duration, maternal income at birth, maternal prepregnancy body mass index, and parental refractive error before childbirth.