Fig. 4.

Cell type gene expression changes demonstrate three patterns across the human lifespan.A. Table of the number of significant differentially expressed genes across aging comparisons: Middle v. Younger age, Older v. Younger age, EL v. Younger age based on fold change threshold of minimum 10% change and FDR less than 0.05. B. Heatmap of scaled average expression per sample of all significant genes across all cell types grouped by age group. C. Boxplots of expression levels of specific significant genes in particular cell types demonstrating changes in aging and EL (Aging-Related) with at least a nominal significance, D. changes only in EL (EL-Specific), and E. changes in aging not in EL (Aging-Specific). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.