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. 2023 Mar 28;72:101716. doi: 10.1016/j.molmet.2023.101716

Figure 2.

Figure 2

Low serine and glycine levels reduce circulating ceramides and complex SL in mice. (A) Log-fold change of all tested metabolites in diet mice subjects compared to control diet mice. Points denote the log-fold change and bars extend to the 95% confidence interval. Bold bars indicate significance after correction for FDR. (B) Correlation plot between human and mice Log-fold change. Pearson correlation coefficient is reported at the top of the figure and the correlation line is displayed in blue. Amino-acids are not contained in this figure as they were artificially altered by design in the mice experiment. Abbreviations: doxDHCer, deoxydihydroceramide; doxCer, deoxyceramide; DHCer, dihydroceramide; Cer, ceramide; Gluc/Gal-Cer or GlucCer, glucosyl/galactosyl-ceramide; Lact-Cer, lactosyl-ceramide; SM, sphingomyelin.