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. 2023 Apr 3;72:101715. doi: 10.1016/j.molmet.2023.101715

Figure 8.

Figure 8

Insulin-resistant GFAT Tg mice display an Sp1-mediated cholesterolgenic response. Age- and weight-matched male and female Tg and Wt littermate control mice fed standard laboratory chow were treated with either saline (+S) or MTM (+M) for 1 wk for determination of (A, B) Body mass (4–5 per group), (C) Skeletal muscle Hmgcr mRNA expression (n = 7–9 per group), and (D) Skeletal muscle membrane cholesterol (n = 4). Data represent means ± SEM. Difference between groups was analyzed using a one-way ANOVA and the Tukey's multiple comparison tests. ∗p < 0.05, ∗∗p < 0.005.