Fig. 1.

Analysis of copy number variation (CNV) and somatic mutation patterns of patients with lung adenocarcinoma (LUAD). A Mutation information statistic of LUAD patients in LUAD cohort of TCGA. B The top 10 most frequently mutated genes from LUAD patients in the cohort of TCGA. Left side of the panel shows the high mutation frequency genes in the waterfall plot, and the colors indicates different mutation types of the high mutation frequency genes in the right panel. (Genes are ordered by their mutation frequencies, and samples are ordered according to disease histology as indicated by the annotation bottom). C Lollipop plot displaying mutation distribution and protein domains for TP53 in LUAD with the labeled recurrent hotspots. Somatic mutation rate and transcript names are indicated by plot title and subtitle. D Schematic representation of the CNV in the TCGA-LUAD, the outermost ring represents the chromosomes, the red ring represents the gene expanded, and the green ring represents the gene deletion. E–G Identification of significantly differing gene amplifications and deletions. False discovery rates (Q-value) and score alteration of GISTIC2.0 (x axis) is plotted versus genome positions (y axis). The broken line represents centromeres. The green line represents the cut-off point of 0.25 Q for determining significance