Table 3.
GSEA enrichment analysis
| ID | NES | P value | P adjust |
|---|---|---|---|
| GSEA GO | |||
| GOCC_DNA_PACKAGING_COMPLEX | 1.976383 | 8.88E−10 | 6.01E−06 |
| GOBP_DNA_PACKAGING | 1.783477 | 2.62E−09 | 8.87E−06 |
| GOBP_DNA_CONFORMATION_CHANGE | 1.668193 | 7.22E−09 | 1.48E−05 |
| GOBP_NUCLEOSOME_ASSEMBLY | 1.902487 | 8.74E−09 | 1.48E−05 |
| GOBP_NUCLEOSOME_ORGANIZATION | 1.81451 | 1.28E−08 | 1.74E−05 |
| GOBP_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY | 1.732312 | 6.18E−08 | 6.97E−05 |
| GOBP_CHROMOSOME_SEGREGATION | 1.616316 | 8.28E−08 | 8.01E−05 |
| GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC | 1.837812 | 1.76E−07 | 0.000149 |
| GOCC_PROTEIN_DNA_COMPLEX | 1.723961 | 2.38E−07 | 0.000179 |
| GOBP_ORGANELLE_FISSION | 1.518382 | 3.71E−07 | 0.000232 |
| GOBP_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION | 1.655031 | 3.77E−07 | 0.000232 |
| GOCC_NUCLEAR_CHROMOSOME | 1.660653 | 5.66E−07 | 0.000315 |
| GOBP_MEIOTIC_CELL_CYCLE_PROCESS | 1.712118 | 6.30E−07 | 0.000315 |
| GOBP_NUCLEAR_CHROMOSOME_SEGREGATION | 1.63877 | 6.51E−07 | 0.000315 |
| GOCC_MULTIVESICULAR_BODY | −2.26426 | 9.31E−07 | 0.00042 |
| GOBP_CHROMATIN_ORGANIZATION_INVOLVED_IN_REGULATION_OF_TRANSCRIPTION | 1.748391 | 1.08E−06 | 0.000458 |
| GOCC_CHROMOSOMAL_REGION | 1.559684 | 1.23E−06 | 0.00049 |
| GOBP_MEIOTIC_CELL_CYCLE | 1.642938 | 1.45E−06 | 0.000544 |
| GOBP_NEURON_FATE_COMMITMENT | 1.902468 | 2.48E−06 | 0.000882 |
| GOMF_SERINE_HYDROLASE_ACTIVITY | −1.74924 | 2.97E−06 | 0.001006 |
| GOCC_CONDENSED_CHROMOSOME | 1.644496 | 3.86E−06 | 0.001245 |
| GOCC_CYTOSOLIC_RIBOSOME | −1.93214 | 4.94E−06 | 0.001518 |
| GOBP_MITOTIC_NUCLEAR_DIVISION | 1.559838 | 1.16E−05 | 0.00342 |
| GOBP_MEIOSIS_I_CELL_CYCLE_PROCESS | 1.723002 | 1.29E−05 | 0.003639 |
| GOBP_DOUBLE_STRAND_BREAK_REPAIR | 1.536981 | 2.65E−05 | 0.006998 |
| GOBP_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC | 1.594629 | 2.69E−05 | 0.006998 |
| GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE | 1.792989 | 2.87E−05 | 0.007197 |
| GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION | 1.653645 | 3.52E−05 | 0.008504 |
| GOBP_REGULATION_OF_NUCLEAR_DIVISION | 1.686256 | 3.66E−05 | 0.008541 |
| GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS | 1.88292 | 4.13E−05 | 0.009313 |
| GOCC_CILIARY_PLASM | −1.74751 | 5.04E−05 | 0.010778 |
| GOCC_BRUSH_BORDER_MEMBRANE | −2.01561 | 5.23E−05 | 0.010778 |
| GOCC_DENSE_CORE_GRANULE | 1.84658 | 5.38E−05 | 0.010778 |
| GOCC_CHROMOSOME_CENTROMERIC_REGION | 1.558626 | 5.42E−05 | 0.010778 |
| GOBP_MEIOTIC_CHROMOSOME_SEGREGATION | 1.732776 | 5.70E−05 | 0.011016 |
| GOCC_CONDENSED_NUCLEAR_CHROMOSOME | 1.724235 | 6.16E−05 | 0.01129 |
| GOBP_SISTER_CHROMATID_SEGREGATION | 1.580149 | 6.22E−05 | 0.01129 |
| GOBP_CILIUM_MOVEMENT | −1.61535 | 6.34E−05 | 0.01129 |
| GOBP_FLUID_TRANSPORT | −2.16657 | 7.20E−05 | 0.012489 |
| GOMF_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY | −2.11512 | 8.01E−05 | 0.013254 |
| GOBP_CHROMATIN_SILENCING | 1.756168 | 8.03E−05 | 0.013254 |
| GOBP_AXONEME_ASSEMBLY | −1.8582 | 9.71E−05 | 0.015641 |
| GOBP_HYDROGEN_PEROXIDE_BIOSYNTHETIC_PROCESS | −2.10282 | 9.95E−05 | 0.015653 |
| GOCC_BRUSH_BORDER | −1.74031 | 0.000108 | 0.016545 |
| GOMF_PEPTIDASE_REGULATOR_ACTIVITY | −1.53378 | 0.000116 | 0.017381 |
| GOBP_DNA_DEPENDENT_DNA_REPLICATION | 1.588182 | 0.000119 | 0.017563 |
| GOBP_CELL_CYCLE_DNA_REPLICATION | 1.751897 | 0.000122 | 0.017604 |
| GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM | −1.55854 | 0.000127 | 0.017821 |
| GOCC_NEURONAL_DENSE_CORE_VESICLE | 1.815389 | 0.000131 | 0.017821 |
| GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION | 1.662135 | 0.000134 | 0.017821 |
| GOBP_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS | 1.813644 | 0.000134 | 0.017821 |
| GOCC_BASAL_PART_OF_CELL | −1.52966 | 0.000145 | 0.01858 |
| GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY | −1.53689 | 0.000146 | 0.01858 |
| GOBP_CENTROMERE_COMPLEX_ASSEMBLY | 1.746264 | 0.00018 | 0.022575 |
| GOBP_DNA_REPLICATION | 1.470602 | 0.000195 | 0.023955 |
| GOBP_RDNA_HETEROCHROMATIN_ASSEMBLY | 1.781571 | 0.000205 | 0.024659 |
| GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY | −1.74739 | 0.000208 | 0.024659 |
| GOBP_HYPOTHALAMUS_DEVELOPMENT | 1.816552 | 0.000235 | 0.026771 |
| GOBP_SENSORY_PERCEPTION_OF_SMELL | 1.412688 | 0.000235 | 0.026771 |
| GOBP_EPITHELIAL_STRUCTURE_MAINTENANCE | −2.07214 | 0.000237 | 0.026771 |
| GOBP_WATER_TRANSPORT | −2.08751 | 0.000252 | 0.027924 |
| GOBP_LIPID_OXIDATION | −1.65664 | 0.000313 | 0.0342 |
| GOMF_HORMONE_ACTIVITY | 1.60724 | 0.000329 | 0.035296 |
| GOBP_HISTONE_EXCHANGE | 1.722975 | 0.00034 | 0.035964 |
| GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION | 1.7319 | 0.000353 | 0.036167 |
| GOBP_MICROTUBULE_BUNDLE_FORMATION | −1.68493 | 0.000353 | 0.036167 |
| GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS | 1.364093 | 0.000405 | 0.04081 |
| GOBP_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM | −2.02779 | 0.000413 | 0.04081 |
| GOCC_MICROVILLUS | −1.69866 | 0.000423 | 0.04081 |
| GOBP_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS | −1.46584 | 0.000424 | 0.04081 |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS | 1.788148 | 0.000428 | 0.04081 |
| GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS | −1.57945 | 0.000451 | 0.042352 |
| GOMF_OLFACTORY_RECEPTOR_ACTIVITY | 1.405798 | 0.000461 | 0.042709 |
| GOMF_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | −2.05169 | 0.000547 | 0.049989 |
| GSEA KEGG | |||
| KEGG_RIBOSOME | −2.32914 | 2.45E−09 | 4.57E−07 |
| KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS | 1.690071 | 4.76E−05 | 0.004424 |
| KEGG_ARACHIDONIC_ACID_METABOLISM | −1.82198 | 0.000218 | 0.013522 |
| KEGG_LINOLEIC_ACID_METABOLISM | −1.93402 | 0.000932 | 0.033491 |
| KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION | −1.54076 | 0.001054 | 0.033491 |
| KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | −1.70657 | 0.00108 | 0.033491 |
| KEGG_FATTY_ACID_METABOLISM | −1.75378 | 0.001699 | 0.045149 |
| GSEA HALLMARK | |||
| HALLMARK_E2F_TARGETS | 1.806064 | 5.45E−09 | 2.72E−07 |
| HALLMARK_G2M_CHECKPOINT | 1.70655 | 4.59E−07 | 1.15E−05 |
| HALLMARK_FATTY_ACID_METABOLISM | −1.52192 | 0.000714 | 0.011892 |
| HALLMARK_SPERMATOGENESIS | 1.507066 | 0.002415 | 0.030192 |