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. 2023 Apr 19;20:28. doi: 10.1186/s12987-023-00431-6

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Permeability of the whole brain BBB to ^99mTc-albumin following CNS treatment. There was no significant multiple-time linear regression in ^99mTc-albumin Brain/Serum (B/S) ratios following (A) IN insulin in males, (B) ICV insulin in males, (C) ICV S961 in males, or (D) ICV S961 in females, indicative of no transport of this vascular marker within the time frame investigated. Each data point represents a single mouse