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. 2023 Apr 19;20:28. doi: 10.1186/s12987-023-00431-6

Table 1.

125I-insulin blood-to-brain pharmacokinetics following intranasal insulin

Brain Group Ki (µl/g-min) p r Vi (µl/g)

Whole

Brain

Vehicle 1.49 ± 0.24 0.193 0.89 4.6 ± 0.9
Insulin 2.05 ± 0.31 0.93 3.8 ± 0.9

Olfactory

Bulb

Vehicle 2.14 ± 0.41 0.366 0.76 11.7 ± 2.9
Insulin 2.74 ± 0.52 0.79 9.7 ± 3.9
Hypothalamus Vehicle 3.76 ± 0.76 0.037 0.93 3.9 ± 3.8
Insulin 0.57 ± 0.88 (ns) 0.35 4.9 ± 2.9

Data in this table are generated from the analysis of the graphs in Fig. 4