Table 2.

Summary of the main preclinical trials testing L-Arg effects in animal models of diabetes

First Author, year [Ref.]	Model
Alba-Roth J, 1988 [6]	Rat anterior pituitary cells co-incubated with L-Arg and GHRH for 3 h
Mohan I.K, 2000 [55]	Insulin-dependent diabetes mellitus model of alloxan-induced diabetic rats
Lass A, 2002 [56]	Rat hearts with oxygen radical-induced myocardial injury. Oxygen radicals were obtained by electrolysis or to hypoxanthine and xanthine oxidase
El Missiry M.A, 2004 [49]	Insulin-dependent diabetes mellitus model of alloxan-induced diabetic rats
Vasilijevic A, 2007 [29].	Insulin-dependent diabetes mellitus model of alloxan-induced diabetic rats
Clemmensen C, 2013 [24]	Diet-induced obese mice
Dubey H, 2022 [13]	Diet and streptozotocin induced diabetic rats

GHRH: Growth Hormone Releasing Hormone