Table 4.
Analysis of prognostic factors influencing overall survival and progression-free survival since diagnosis in ED-SCLC
| Characteristics | OS since diagnosis | PFS since diagnosis | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Sex | ||||||||
| Male | Ref. | Ref. | ||||||
| Female | 1.0 (0.6–1.6) | 0.92 | 1.0 (0.5–1.8) | 0.99 | 1.0 (0.6–1.6) | 0.94 | 1.1 (0.6–2.0) | 0.73 |
| Age | 1.0 (1.0–1.0) | 0.27 | 1.0 (1.0–1.0) | 0.61 | 1.0 (1.0–1.0) | 0.67 | 1.0 (1.0–1.0) | 0.55 |
| Karnofsky | ||||||||
| 80–100 | Ref. | Ref. | ||||||
| < 80 | 2.7 (1.6–4.7) | < 0.001 | 2.4 (1.3–4.5) | 0.01 | 1.9 (1.2–3.2) | 0.01 | 1.7 (0.9–3.0) | 0.10 |
| T-Classification | ||||||||
| T1 | Ref. | Ref. | ||||||
| T2 | 0.6 (0.2–1.9) | 0.36 | 0.9 (0.2–4.8) | 0.93 | 0.3 (0.1–1.1) | 0.06 | 0.3 (0.1–1.4) | 0.13 |
| T3 | 1.1 (0.3–3.5) | 0.88 | 1.6 (0.4–6.9) | 0.53 | 0.6 (0.2–2.0) | 0.43 | 0.7 (0.2–2.4) | 0.53 |
| T4 | 0.8 (0.3–2.3) | 0.66 | 1.2 (0.3–5.5) | 0.78 | 0.6 (0.2–1.7) | 0.31 | 0.5 (0.1–1.8) | 0.28 |
| N-Classification | ||||||||
| N0 | Ref. | Ref. | ||||||
| N1 | 0.2 (0.0–2.4) | 0.23 | 1.3 (0.1–21.7) | 0.85 | 0.2 (0.0–1.8) | 0.15 | 0.4 (0.0–5.0) | 0.44 |
| N2 | 1.2 (0.2–9.3) | 0.84 | 3.7(0.3–41.3) | 0.29 | 0.7 (0.1–5.3) | 0.73 | 1.2 (0.1–12.4) | 0.87 |
| N3 | 0.7 (0.1–5.4) | 0.76 | 3.4 (0.3–41.0) | 0.34 | 0.7 (0.1–5.2) | 0.74 | 1.5 (0.1–15.5) | 0.74 |
| Start during cycle | ||||||||
| Early start | Ref. | Ref. | ||||||
| Late start | 0.1 (0.0–0.4) | 0.001 | 0.1 (0.0–0.5) | 0.01 | 0.2 (0.1–0.6) | 0.01 | 0.3 (0.1–1.4) | 0.14 |
| Very late start | 0.3 (0.1–0.6) | 0.003 | 0.2 (0.0–0.7) | 0.01 | 0.3 (0.1–0.7) | 0.01 | 0.4 (0.1–1.1) | 0.09 |