Table 8.
Analysis of prognostic factors influencing overall survival and progression-free survival since thoracic irradiation in ED-SCLC
| Characteristics | OS since first irradiation | PFS since first irradiation | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Sex | ||||||||
| Male | Ref. | Ref. | ||||||
| Female | 1.1 (0.6–1.8) | 0.75 | 1.1 (0.6–2.0) | 0.83 | 1.0 (0.6–1.7) | 0.92 | 1.1 (0.6–2.0) | 0.74 |
| Age | 1.0 (1.0–1.0) | 0.10 | 1.0 (1.0–1.0) | 0.58 | 1.0 (1.0–1.0) | 0.61 | 1.0 (1.0–1.0) | 0.70 |
| Karnofsky | ||||||||
| 80–100 | Ref. | Ref. | ||||||
| < 80 | 3.2 (1.8–5.6) | < 0.001 | 2.7 (1.4–5.5) | 0.005 | 2.2 (1.3–3.7) | 0.004 | 1.9 (1.0–3.7) | 0.05 |
| T-Classification | ||||||||
| T1 | Ref. | Ref. | ||||||
| T2 | 1.0 (0.3–3.6) | 0.94 | 2.0 (0.4–9.4) | 0.37 | 0.9 (0.3–3.2) | 0.87 | 1.1 (0.3–4.3) | 0.94 |
| T3 | 1.5 (0.5–4.8) | 0.49 | 2.0 (0.5–8.4) | 0.32 | 1.3 (0.4–4.0) | 0.64 | 1.3 (0.4–4.3) | 0.72 |
| T4 | 1.2 (0.4–3.4) | 0.71 | 2.0 (0.5–7.2) | 0.30 | 1.2 (0.4–3.5) | 0.69 | 1.2 (0.4–3.6) | 0.80 |
| N-Classification | ||||||||
| N0 | Ref. | Ref. | ||||||
| N1 | 0.4 (0.0–3.7) | 0.39 | 0.5 (0.0–8.2) | 0.66 | 0.3 (0.0–2.8) | 0.27 | 0.2 (0.0–2.2) | 0.17 |
| N2 | 2.5 (0.3–19.1) | 0.37 | 2.4 (0.2–28.6) | 0.48 | 2.2 (0.3–16.3) | 0.46 | 1.2 (0.1–12.3) | 0.90 |
| N3 | 1.2 (0.2–8.6) | 0.88 | 1.3 (0.1–17.0) | 0.82 | 1.4 (0.2–10.0) | 0.76 | 0.8 (0.1–8.6) | 0.84 |
| Start during cycle | ||||||||
| Early start | Ref. | Ref. | ||||||
| Late start | 0.2 (0.1–0.8) | 0.02 | 0.2 (0.0–1.3) | 0.09 | 0.5 (0.2–1.7) | 0.29 | 1.1 (0.3–4.3) | 0.88 |
| Very late start | 0.6 (0.2–1.4) | 0.22 | 0.5 (0.2–1.8) | 0.31 | 1.0 (0.4–2.1) | 0.91 | 1.3 (0.5–3.5) | 0.54 |