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. 2023 Apr 19;21:79. doi: 10.1186/s12964-023-01106-3

Table 4.

Based on the results of cell line investigations, it can be seen how miRNA-93 contributes to the pathogenesis of diseases

Disease type miRNA type Interactions Cell lines Associated phenotype with dysregulation of miRNA-93 Ref
Acute myocardial infraction miRNA-93-5p TLR4/NF-κB-Mediated Inflammatory Response H9c2 ↑miRNA-93-5p, ↓Atg7-mediated autophagy and TLR4-mediated inflammatory: ↓myocardial injury [105]
Acute kidney injury miRNA-93 IRAK4/NF-κB and IL-6R/STAT3 HK-2 ↑SNHG14, ↓ miRNA-93, ↑IRAK4/NF-κB and IL-6R/STAT3 signaling: ↑Sepsis-Induced Acute Kidney Injury [104]
Atherosclerosis miRNA-93 ABCA1 THP1 ↑miRNA-93, ↓ ABCA1: ↑ disease progression