TABLE 3.
Diagnostic performance in using Quad test based on Western specific reference model with ethnic correction and Thai-specific reference model (Down screening, Chiang Mai, Thailand, 2016–2021).
| Down syndrome pregnancy (n = 74) | Normal pregnancy (n = 39,666) | Total (n = 39,740) | Sensitivity (95% CI) | Specificity (95% CI) | False positive rate (95% CI) | |
|---|---|---|---|---|---|---|
| Western model with ethnic correction | ||||||
| High risk | 60 (81.1%) | 2,839 (7.2%) | 2,899 (7.3%) | 81.1 (72.2–90.0) | 92.8 (92.6–93.1) | 7.2 (6.9–7.4) |
| Low risk | 14 (18.9%) | 36,827 (92.8%) | 36,841 (92.7%) | |||
| Thai-specific reference model | ||||||
| High risk | 65 (87.8%) | 2,711 (6.8%) | 2,776 (7%) | 87.8 (80.4–95.3) | 93.2 (92.9–93.4) | 6.8 (6.6–7.0) |
| Low risk | 9 (12.2%) | 36,955 (93.2%) | 36,964 (93%) | |||