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. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: Crit Care Med. 2017 Sep;45(9):1523–1530. doi: 10.1097/CCM.0000000000002577

Figure 1. Trauma causes expansion of CD4+ Th17 cells all time points after injury, with constitutive activation at day 5.

Figure 1

A. Biaxial plots of representative samples from each experimental group showing increased RORγT expression in CD3+CD4+ gated T cells after injury, plotted as DNA+ vs RORγT+. B. RORγT expression in CD4+ T cells increases significantly at all time points after injury, with a peak at day 3. C. IL-17F expression in CD4+ T cells remains low after injury until day 5, at which time there is a high level of expression in both unstimulated samples as well as samples stimulated with anti CD3/CD28 antibodies. Statistics were performed using one-way ANOVA; results were considered significant if p < 0.05.