Fig. 1.
Effect of DOI on HTR in male (n = 12–15) and female (n = 10–15) C57BL/6J mice. A) Time-course showing HTR counts in 15 min blocks corresponding to different doses of DOI (0.5 mg/kg and 2 mg/kg) or vehicle. Back arrow shows the administration time-point (t = 0). B) Sum of HTR during the first 30 min after DOI or vehicle administration. C) Sum of HTR during 45–90 min after DOI or vehicle administration. Two-way ANOVA followed by Bonferroni’s post hoc test (**P < 0.01, ***P < 0.001). For a three-way ANOVA analysis, see Table 1. Data show mean ± S.E.M.