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. 2023 Apr 17;220(7):e20221649. doi: 10.1084/jem.20221649

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Figure 4. — The developmental defect in OT2 TCR transgenic Grb2-deficient thymocytes is rescued by deletion of Shp1 (Ptpn6) and exacerbated by overexpression of SHP1. (A) Phenotype of thymocytes (left panels) and splenocytes (right panels) from the indicated mice. (B) Phenotype of OT2 TCR transgenic Themis^−/− mice and rescue of the developmental defect in OT2 TCR transgenic Themis^−/− mice by deletion of Shp1 (Ptpn6) shown for comparison to A. Numbers indicate percentage of cells in the indicated gate. Data shown are representative of at least four mice for each genotype. Efficient Cre-mediated deletion was confirmed in all cases where appropriate by Western blot.